High Content Screening Drug Discovery

1 but the last ten years have certainly disproved those claims with hts playing a role in the discovery of many new drugs and moving from the preserve of large pharma to a method available to smaller companies.

High content screening drug discovery.

In this study we present a novel high content screening assay which is highly predictive for human drug induced liver injury dili. Hence high content screening is a type of phenotypic screen conducted in cells involving the analysis of whole cells or. Read more optimising phenotypic screening single cell analysis versus 3d multicell analysis by dr richard m. Discovery of a novel rock2 inhibitor with anti migration effects via docking and high content drug screening 1 january 2016 molecular biosystems vol.

In most pharmaceutical and biotechnology companies there is a need to always improve the quality of lead candidates. 9 high content screening identifies inhibitors of the nuclear translocation of atf6. High content screening hcs has played a significant role in infectious disease research and drug discovery to date and can be a strong tool in the age of covid 19 and beyond. Recent developments in high content screening hcs technologies make it an attractive alternative for anti angiogenic drug discovery.

Hcs integrates high throughput methodologies with automated multicolor fluorescence microscopy to collect quantitative morphological and molecular data from complex biological systems. Drug discovery in its early history used to be conducted mainly in a target agnostic fashion focusing on qualitative readouts from a living system cells tissue or organisms and asking the question did this entity affect the phenotype. High content screening hcs also known as high content analysis hca or cellomics is a method that is used in biological research and drug discovery to identify substances such as small molecules peptides or rnai that alter the phenotype of a cell in a desired manner. This demand resulted in the use of cell based screening as a method of choice in drug discovery 1 2 high content screening hcs is multiplexed functional cell based screening 3 4 5 6 hcs can be used in all aspects of drug discovery as an engine for driving.

Paper phenotypic drug discovery with high content screening target based or phenotypic screening. These types of assays are often referred to as high content screening or high content analysis hcs hca.